Red blood cell transfusion thresholds in pediatric septic patients

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Red blood cell transfusion thresholds in pediatric patients with sepsis.

OBJECTIVES In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on clinical outcome. DESIGN Subgroup analysis of a prospective, multicenter, rando...

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Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies

BACKGROUND Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe sepsis and septic shock in patients with hematological malignancies. METHODS We performed a retrospective analysis of a prospectively collected database of patients with hema...

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Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients

BACKGROUND Red blood cell (RBC) transfusion is commonly used to increase oxygen transport in patients with sepsis. However it does not consistently increase oxygen uptake at either the whole-body level, as calculated by the Fick method, or within individual organs, as assessed by gastric intra-mucosal pH. AIM This study evaluates the hemodynamic and oxygen utilization effects of hemoglobin in...

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Leukodepleted versus nonleukodepleted red blood cell transfusion in septic patients: a microcirculatory vision

Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of leukodepletion on microcirculation remains not well defined in ICU patients. In ...

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ژورنال

عنوان ژورنال: Critical Care

سال: 2011

ISSN: 1364-8535

DOI: 10.1186/cc9848